Overweight children and adolescents who receive chemotherapy for treatment of leukemia have less success in combating the disease compared to skinny teenagers.
The research conducted in the Cancer and Blood Disease Institute do Children’s Hospital Los Angeles, USA, shows that small changes in diet it is us Exercises can greatly increase the survival of young people on treatment for Acute lymphoblastic leukemia (ALL), or cancer most common infantile.
“As far as we know, this is the first study to show that by limiting calories and increasing exercise, we can make chemotherapy more effective in eliminating leukemic cells in the first month of therapy, decreasing the likelihood of disease recurrence in children and adolescents, ”said researcher Etan Orgel, Director of the Support Medical Care Service at the Cancer and Blood Disease Institute do Children’s Hospital Los Angeles. The study was published in the journal “Blood Advances” gives American Society of Hematology.
Obese young people when they start chemotherapy are twice as likely to have cancer cells remaining after a month of treatment – and a greater likelihood of relapse of the disease – compared to thin young people. To address this, the researchers worked with nutritionists and physical therapists to create personalized diet plans and exercises for 40 patients aged 10 to 21 with newly diagnosed leukemia.
The researchers found that patients who reduced their caloric intake by at least 10% and started a regimen of some exercise started with a diagnosis, on average, with 70% less likely to have leukemia cells remaining in the bone marrow one month after the initiation of chemotherapy, compared to previously treated patients who did not participate in diet and exercise. The remaining leukemia cells are one of the strongest predictors of poor survival outcomes.
“This is a proof of concept that it is possible to increase the effectiveness of chemotherapy without adding other drugs with potential side effects,” said Etan Orgel, and added: “This short-term intervention is inexpensive and easily available to families anywhere. . ”
The researchers found that by limiting fat, patients also decreased insulin resistance, as well as increased levels of adiponectin, a metabolic hormone associated with glucose regulation. The identification of these potential biomarkers paves the way for the use of this intervention to impact other types of cancer.
“Changing diet and exercise made chemotherapy work better – that’s the big news in this study. But we also need to find out how “this is done,” said Steven Mittelman, Head of Pediatric Endocrinology at University of California Children’s Hospital, Los Angeles, (UCLA) Mattel, and a member of the Jonsson Comprehensive Cancer Center of UCLA. “Understanding the biological changes responsible for this effect will help us make these interventions even better.”
To send a suggestion, please do or.
Get the latest news delivered to your inbox
Follow us on social media networks