Mutations Discovered That Accelerate Heart Failure Progression

Mutations Discovered That Accelerate Heart Failure Progression
Mutations Discovered That Accelerate Heart Failure Progression
O The work, whose conclusions are published today in the North American journal of the College of Cardiology (The Journal of the American College of Cardiology – JACC), was developed by a multidisciplinary team of scientists and doctors from the National Center for Cardiovascular Research (CNIC) and Virgen de Arrixaca hospitals in Murcia and Germans Trias and Pujol in Badalona.

Heart failure is the main reason for hospitalization for people over 65 and an important cause of death, underlined today the National Center for Cardiovascular Research, emphasizing that the results of this investigation open the door to the development of personalized therapies aimed at patients with this type of mutations.

Each day, an adult person generates hundreds of billions of blood cells, a necessary process that, however, facilitates the appearance of mutations in the cells that are responsible for their production.

These mutations are called somatic, since they occur due to acquired, non-hereditary changes in the DNA of these progenitor cells and, although most of them are innocuous changes, sometimes they cause the cells to acquire a competitive advantage that allows them to expand progressively, which causes clones in the blood.

The study’s principal investigator, José Javier Fuster, specified that the results indicate that these mutations represent a new cardiovascular risk factor and explain why some people apparently at low risk develop these pathologies, especially among the adult population.

Speaking to the agency Efe, Fuster stressed that in the short term the results may contribute to identifying and monitoring patients at greater risk of suffering this progression of heart failure and, in the long term, mitigating the effects with anti-inflammatory drugs, despite having insisted that there are still several years of research and clinical trials to be carried out.

Virtually all people suffer this mutation throughout their lives, but the process only develops in some, noted Fuster, who insisted on the importance of identifying strategies (pharmacological or lifestyle) that delay this process or even reverse it.

The researchers found that the presence of these acquired mutations in blood cells suggests a high risk of accelerated progression of heart failure.

The problem is directly related to aging, so as people get older the chances of this process increasing, explained Fuster, the research coordinator.

The same official recalled that some recent studies have shown that individuals with the problem are at greater risk of developing hematological cancers and dying, but that death is not caused by cancer, but by cardiovascular causes.

Also Read: Understand and prevent a Stroke? DGS’s explanations

Always be the first to know.
Fifth consecutive year Consumer Choice for Online Press.
Download our free App.

Google Play Download

Get the latest news delivered to your inbox

Follow us on social media networks

PREV Young people cross border with Uruguay due to vaccine against covid-19: ‘In Brazil, it would take too long’ – 04/05/2021
NEXT Primer on breast cancer prevention is available for free